Fig. 1.

LEDGF/p75 plays a vital role in tumors and other diseases. (A) Physical interactions of LEDGF/p75 and other key proteins indicate potential functions of LEDGF/p75. (B) LEDGF/p75 binds to histones and several histone modification proteins. The purple lines represent experimentally determined interactions, and the blue lines show the results from curated databases. (C) Predicted scores of LEDGF/p75 in cancers and other diseases based on protein—protein interactions. Different colors represent different rating levels of the canSAR database. (D) Correlations between LEDGF/p75 expression and 5 histone modification genes in pancancer. (E-G) Results of GSEA-KEGG analyses. * P < 0.05, * * P < 0.01, * ** P < 0.001.