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. 2023 Aug 26;21:4134–4148. doi: 10.1016/j.csbj.2023.08.023

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© 2023 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 8 — LEDGF/p75 knockdown in ccRCC causes changes in cancer-related genes and pathways. (A) Heatmap of differentially expressed genes in different groups. (B) Volcano plot of differentially expressed genes after knockdown of LEDGF/p75. (C) Gene Ontology (GO) analysis of all regulated genes. (D) GO analysis of downregulated genes. (E) Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of all regulated genes. (F) KEGG analysis of all downregulated genes.