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. 2023 Jun 9;22(9):999–1012. doi: 10.1158/1535-7163.MCT-22-0786

Figure 3.

Figure 3. In vivo profile comparison of B7-H4 ADCs. A, Antitumor activity of B7-H4 ADCs in HBCx-24 PDX model. Inset, B7-H4 IHC. B, Antitumor activity of B7-H4 ADCs in MX-1 breast cancer cell line model. Inset, B7-H4 IHC. C, Plasma levels of conjugated drug in MX-1 tumor-bearing animals following a single administration of ADC at 0.15 mg/kg payload. Refer to legend in part B. D, Plasma levels of three analytes in cynomolgus monkeys following a single administration of ADC at 0.09 mg/kg payload. Blue, XMT-1660 DAR 6 DS; purple, DAR 2 DS.

In vivo profile comparison of B7-H4 ADCs. A, Antitumor activity of B7-H4 ADCs in HBCx-24 PDX model. Inset, B7-H4 IHC. B, Antitumor activity of B7-H4 ADCs in MX-1 breast cancer cell line model. Inset, B7-H4 IHC. C, Plasma levels of conjugated drug in MX-1 tumor-bearing animals following a single administration of ADC at 0.15 mg/kg payload. Refer to legend in part B. D, Plasma levels of three analytes in cynomolgus monkeys following a single administration of ADC at 0.09 mg/kg payload. Blue, XMT-1660 DAR 6 DS; purple, DAR 2 DS.