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. 2023 Jun 9;22(9):999–1012. doi: 10.1158/1535-7163.MCT-22-0786

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©2023 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 5. XMT-1660 activity across a panel of breast cancer PDX. A, Waterfall plot of MBR among n = 3 per PDX model. Pink bars, TNBC. Green bars, ER+ breast cancer. B, The data from part A shown with B7-H4 IHC score in each model. Inset, responsive (MBR ≤ −0.3) and nonresponsive tumors when categorized by B7-H4 IHC as low TPS (< 75) or high TPS (≥75). C, Representative B7-H4 IHC images from pink (TNBC) and green (ER+) PDX models with low TPS (<75) and high TPS (≥75). — XMT-1660 activity across a panel of breast cancer PDX. A, Waterfall plot of MBR among n = 3 per PDX model. Pink bars, TNBC. Green bars, ER+ breast cancer. B, The data from part A shown with B7-H4 IHC score in each model. Inset, responsive (MBR ≤ −0.3) and nonresponsive tumors when categorized by B7-H4 IHC as low TPS (< 75) or high TPS (≥75). C, Representative B7-H4 IHC images from pink (TNBC) and green (ER+) PDX models with low TPS (<75) and high TPS (≥75).