Figure 4.

Evaluating cross-species GO term matching demonstrates that functional gene sets have consistently stronger correspondence than other methods. The alignment between H. sapiens and four model organisms (M. musculus, S. cerevisiae, D. melanogaster, C. elegans) are considered. There are 645, 292, 349, and 129 shared GO terms, respectively. We calculated a z-score for connectivity between genes annotated to the same GO term across species against a null distribution generated from random degree-matched gene sets of the same size. The dotted line is the z-score that corresponds to the Bonferroni corrected P-value=.05.