Table 1.

Publications detailing Mendelian randomization and genetic correlation analyses with endometriosis.

Trait category	Traits	Methods	Ancestry	Publication
Pain	Migraine	Genetic correlation and Mendelian randomization	Endometriosis: 93% European, 7% Japanese Migraine: European	Adewuyi et al. (2020)
		Genetic correlation	Australian	Nyholt et al. (2009)
Gynaecological conditions	Age at menarche, age at menopause, AMH levels, reproductive hormone levels and length of menstrual cycle	Mendelian randomization	Endometriosis: Finnish Age at menarche, age at menopause, AMH levels, reproductive hormone levels and length of menstrual cycle: European	Garitazelaia et al. (2021)
	Uterine fibroids	Genetic correlation and Mendelian randomization	Endometriosis: European Uterine fibroids: European	Gallagher et al. (2019)
	Age at first birth and age at first sexual intercourse	Genetic correlation	Endometriosis: European Age at first birth and age at first sexual intercourse: European	Mills et al. (2021)
Cancer	Epithelial ovarian cancer and epithelial ovarian cancer subtypes	Genetic correlation and Mendelian randomization	Endometriosis: European Epithelial ovarian cancer and epithelial ovarian cancer subtypes: European	Mortlock et al. (2022)
		Mendelian randomization	Endometriosis: European Epithelial ovarian cancer and epithelial ovarian cancer subtypes: European	Lu et al. (2015)
		Mendelian randomization	Endometriosis: 93% European, 7% Japanese Epithelial ovarian cancer and Epithelial ovarian cancer subtypes: European	Yarmolinsky et al. (2019)
	Ovarian cancer, ovarian cancer subtypes, breast cancer, endometrial cancer	Mendelian randomization	Endometriosis: 93% European, 7% Japanese Ovarian cancer, ovarian cancer subtypes, breast cancer, endometrial cancer: European	Rueda-Martinez et al. (2021)
	Melanoma	Genetic correlation and Mendelian randomization	Endometriosis: European Melanoma: European	Yang et al. (2021)
	Endometrial cancer	Genetic correlation	Endometriosis: Australian and UK Endometrial cancer: Australian and UK	Painter et al. (2018)
		Genetic correlation and Mendelian randomization	Endometriosis: 0.5% Japanese, 99.5% European Endometrial cancer: European	Kho et al. (2021)
Inflammatory	Asthma	Genetic correlation and Mendelian randomization	Endometriosis: 93% European, 7% Japanese Asthma: European	Adewuyi et al. (2022)
	Coeliac disease, systemic lupus erythematosus, Sjögren’s syndrome, rheumatoid arthritis, and multiple sclerosis	Mendelian randomization	Endometriosis: Finnish Coeliac disease, systemic lupus erythematosus, Sjögren’s syndrome, rheumatoid arthritis, and multiple sclerosis: European	Garitazelaia et al. (2021)
Gastrointestinal	Gastritis/duodenitis, gastro-oesophageal reflux disease	Genetic correlation and Mendelian randomization	Endometriosis: European (93%), Japanese (7%) Gastritis/duodenitis, gastro-oesophageal reflux disease: European	Adewuyi et al. (2021)
Psychological	Depression	Genetic correlation and Mendelian randomization	Endometriosis: European (93%), Japanese (7%) Depression: European	Adewuyi et al. (2021)
Anthropometric	Weight, BMI, height, WHR	Mendelian randomization	Endometriosis: Finnish Weight, BMI, height, waist-to-hip ratio (WHR): European	Garitazelaia et al. (2021)
	Birth weight	Mendelian randomization	Endometriosis: Finnish Birth weight: European	He et al. (2022)
	BMI, WHR and WHRadjBMI, each adjusted for leptin, fasting insulin and insulin sensitivity separately, as well as unadjusted Leptin, fasting insulin, and insulin sensitivity each adjusted for BMI, WHR and WHRadjBMI separately, as well as unadjusted visceral adipose tissue mass	Mendelian randomization	Endometriosis: Australia and UK, UKB and FinnGen BMI, WHR, WHRadjBMI: European. VAT mass: UKB individuals of British descent. Leptin, fasting insulin, insulin sensitivity: European.	Venkatesh et al. (2022)
	Adulthood and childhood BMI	Mendelian randomization	Endometriosis: UKB Adulthood and childhood BMI: European	Yan et al. (2022)
	BMI	Mendelian randomization	Endometriosis: Japanese BMI: Japanese	Masuda et al. (2020)

AMH, anti-Müllerian Hormone; UKB, UK Biobank; WHR, waist-to-hip ratio.