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. Author manuscript; available in PMC: 2024 May 10.
Published in final edited form as: Cell Host Microbe. 2023 May 1;31(5):827–838.e3. doi: 10.1016/j.chom.2023.04.007

Figure 4: Association of gut microbiome functional features associated with adenoma subtypes.

Figure 4:

(A) Barplot of 363 significant microbial EC functional features (FDR <0.2), agglomerated to their parent metabolic pathway function, associated with either SSAs or TAs. (B) Patients with tubular adenomas also have significant negative associations with microbial features associated with methanogen metabolism, with (C) corresponding lower abundance of methanogenic microbial species - Methanobrevibacter smithii. (D) Participants with either SSAs or TAs have the most numbers of positive associations with amino acid metabolism, whereas amino-acid related pathways include both essential and non-essential amino-acids (E) Volcano plots highlighting predicted metabolites with increased or decreased abundance in either TA or SSA.