Figure 5: Interplay of environmental factors and gut microbiome features associated with adenoma subtypes.
(A) Significant dietary-microbe and medication-microbe correlations associations limited to significant microbial species identified to be associated with either TAs (A) or SSAs (B) in GIDER, are plotted in this network correlation plot. Network shows all significant correlations (FDR < 0.05) between each pair of measurement types. Nodes coloured by class of environmental factor and sized by number of associations, lines by sign and strength of association (red for positive correlation, blue for negative correlation). (B) Mediation plots demonstrating statistically significant environmental exposure and microbe effects on tubular adenomas.