Table 5.
The minimum inhibitory concentrations (MIC) against H37Rv Mycobacterium tuberculosis (Mtb) afforded by compounds 1, 151-d and 16b.
| |||||||
|---|---|---|---|---|---|---|---|
| Compound | R1 | R2 | cLogPa | H37Rv Mtb MIC (μM) | |||
| GAST-Fe | 7H9/ADC | 7H9/glucose | 7H9/DPPC | ||||
| 1 |
|
|
1.6 | > 100 | > 100 | > 100 | > 100 |
| 15a |
|
|
3.6 | > 100 | > 100 | 100 | 9.4 |
| 15b |
|
|
3.6 | > 100 | > 100 | > 100 | 12.5 |
| 15c |
|
|
4.1 | > 100 | > 100 | 25 | 9.4 |
| 15d |
|
|
4.1 | > 100 | > 100 | 9.4 | 6.3 |
| 16b |
|
|
2.1 | > 100 | > 100 | 25 | 19 |
a
Calculated using ChemDraw (PerkinElmer, Waltham MA).