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. Author manuscript; available in PMC: 2023 Sep 5.
Published in final edited form as: J Med Chem. 2019 Sep 27;62(23):10586–10604. doi: 10.1021/acs.jmedchem.9b01203

Table 5.

The minimum inhibitory concentrations (MIC) against H37Rv Mycobacterium tuberculosis (Mtb) afforded by compounds 1, 151-d and 16b.

graphic file with name nihms-1928410-t0042.jpg
Compound R1 R2 cLogPa H37Rv Mtb MIC (μM)
GAST-Fe 7H9/ADC 7H9/glucose 7H9/DPPC
1 graphic file with name nihms-1928410-t0043.jpg graphic file with name nihms-1928410-t0044.jpg 1.6 > 100 > 100 > 100 > 100
15a graphic file with name nihms-1928410-t0045.jpg graphic file with name nihms-1928410-t0046.jpg 3.6 > 100 > 100 100 9.4
15b graphic file with name nihms-1928410-t0047.jpg graphic file with name nihms-1928410-t0048.jpg 3.6 > 100 > 100 > 100 12.5
15c graphic file with name nihms-1928410-t0049.jpg graphic file with name nihms-1928410-t0050.jpg 4.1 > 100 > 100 25 9.4
15d graphic file with name nihms-1928410-t0051.jpg graphic file with name nihms-1928410-t0052.jpg 4.1 > 100 > 100 9.4 6.3
16b graphic file with name nihms-1928410-t0053.jpg graphic file with name nihms-1928410-t0054.jpg 2.1 > 100 > 100 25 19
a

Calculated using ChemDraw (PerkinElmer, Waltham MA).