Table 2.

Study visits and procedures.

Visit	Washout	1	2	3		4		5
Week	−2	0	4a	8a	12a	26a	38a	52
Informed consent taking	×b	×b			Phone call follow-up		Phone call follow-up
Demographics and anthropometrics collection	×b	×b
Collection of past medical history, including medications	×b	×b
Urine pregnancy test	×	×	×	×		×		×
Randomization		×
Health-related quality of life assessment		×				×		×
Study medication dispense		×	×	×		×
Medication adherence check		×	×	×		×		×
Blood collection for renal function and potassium level		×	×	×		×		×
Blood collection for hematocrit		×						×
Blood collection for storage		×						×
Office blood pressure measurement		×	×	×		×		×
24-h ambulatory blood pressure monitoring		×	×	×		×		×
Cardiovascular magnetic resonance		×						×
Adverse events evaluation		×	×	×		×		×

^a Additional clinic visits are arranged if necessary.

^b These procedures are only done once, either at the washout visit or visit 1.