Figure 3. Chronic uveitis-derived memory T cells show antigen-specific activation in response to in vitro re-stimulation.

The sorted memory (CD44^hi) and control (CD44^−~lo) cells from CAU mice were in vitro stimulated with the uveitogenic antigen (IRBP) for 18 hours. Antigen-responding T cells were detected by CD154 expression (A) and pathogenic cytokines production (B). No antigen-stimulated CD44^hiCD4⁺ cell cultures served as the unstimulated control. Data in bar graphs represent mean ± SEM from one experiment out of two performed. **, p < 0.01; ***, p < 0.001; ns, not significant.