Table 3.
Adjusted percent difference (95% CI) in NT-pro-BNP according to measures of body composition among US adults aged 20 or older, NHANES 1999–2004.
| Men | Women | |||||||
|---|---|---|---|---|---|---|---|---|
| NT-pro-BNP | Waist Circumference—Quartiles | Waist Circumference—Quartiles | ||||||
| Q1 (62.4–89.3) | Q2 (89.4–97.9) | Q3 (98.0–107.9) | Q4 (108.0–173.4) | Q1 (62.0–81.3) | Q2 (81.4–90.8) | Q3 (90.9–102.4) | Q4 (102.5–155.9) | |
| Mean (95% CI), pg/mL | 23.4 (21.6–25.3) | 26.8 (24.7–29.1) | 28.8 (26.9–30.8) | 32.4 (30.2–34.8) | 63.09 (59.00–67.46) | 62.88 (58.72–67.33) | 61.83 (57.91–66.01) | 59.11 (55.68–62.75) |
| % difference (95%CI) | 0 | −10.83 (−18.67 to −2.24) | −19.80 (−26.57 to −12.41) | −15.20 (−23.81 to −5.62) | −12.97 (−20.02 to −5.29) | −24.00 (−30.19 to −17.26) | −27.45 (−33.59 to −20.74) | |
| Body Mass Index (kg/m2)—Clinical Categories | Body Mass Index (kg/m2)—Clinical Categories | |||||||
| 18.5–<25 kg/m2 | 25–<30 kg/m2 | 30–<35 kg/m2 | BMI ≥ 35 kg/m2 | 18.5–<25 kg/m2 | 25–<30 kg/m2 | 30–<35 kg/m2 | BMI ≥ 35 kg/m2 | |
| Mean (95% CI), pg/mL | 28.71 (26.49–31.12) | 26.69 (25.12–28.36) | 27.56 (24.89–30.51) | 28.99 (25.75–32.63) | 67.11 (63.97–70.40) | 62.64 (58.88–66.64) | 56.30 (52.01–60.94) | 54.18 (49.93–58.78) |
| % difference (95% CI) | 0 | −19.43 (−26.50 to −11.68) | −18.77 (−26.94 to −9.70) | −12.06 (−21.84 to −1.05) | −15.04 (−20.37 to −9.35) | −22.34 (−28.17 to −16.04) | −24.30 (−29.92 to −18.22) | |
| Body Mass Index (kg/m2)—Quartiles | Body Mass Index (kg/m2)—Quartiles | |||||||
| Q1 (18.5–24.4) | Q2 (24.4–27.3) | Q3 (27.3–30.5) | Q4 (30.5–64.2) | Q1 (18.5–23.2) | Q2 (23.2–26.8) | Q3 (26.9–32.0) | Q4 (32.0–66.4) | |
| Mean (95% CI), pg/mL | 29.32 (26.94–31.90) | 27.43 (25.19–29.85) | 25.67 (23.81–27.67) | 28.38 (26.33–30.59) | 67.45 (62.61–72.67) | 65.12 (61.27–69.23) | 60.80 (56.06–65.94) | 54.27 (50.67–58.13) |
| % difference (95% CI) | 0 | −16.12 (−24.79 to −6.46) | −25.58 (−33.33 to −16.93) | −18.91 (−26.16 to −10.95) | 0 | −12.74 (−19.95 to −4.89) | −20.55 (−27.02 to −13.50) | −27.61 (−33.54 to −21.16) |
| Fat Mass Index (kg/m2)—Quartiles | Fat Mass Index (kg/m2)—Quartiles | |||||||
| Q1 (2.2–6.0) | Q2 (6.0–7.7) | Q3 (7.7–9.6) | Q4 (9.6–27.7) | Q1 (3.7–8.4) | Q2 (8.4–11.0) | Q3 (11.0–14.2) | Q4 (14.2–36.4) | |
| Mean (95% CI), pg/mL | 25.99 (23.93–28.23) | 24.86 (22.74–27.18) | 27.12 (25.15–29.24) | 30.10 (27.63–32.78) | 63.05 (58.69–67.73) | 62.62 (58.17–67.42) | 57.32 (53.02–61.97) | 58.00 (53.65–62.70) |
| % difference (95% CI) | 0 | −23.06 (−30.93 to −14.30) | −22.81 (−30.63 to −14.10) | −18.73 (−26.67 to −9.93) | 0 | −15.74 (−22.84 to −7.97) | −24.46 (−30.40 to −18.01) | −24.23 (−30.93 to −16.87) |
| % difference (95% CI)—LMI adjustmenta | 0 | −19.45 (−27.96 to −9.93) | −16.30 (−25.00 to −6.59) | −8.19 (−18.57–3.52) | 0 | −11.28 (−19.44 to −2.30) | −12.85 (−21.55 to −3.19) | 0.08 (−14.44–17.07) |
| % difference (95% CI)—BMI adjustmenta | 0 | −17.22 (−26.41 to −6.87) | −12.08 (−23.01–0.41) | 0.83 (−15.24–19.95) | 0 | −6.69 (−16.85–4.72) | −5.54 (−18.52–9.52) | 14.46 (−10.24–45.96) |
| % difference (95% CI)—WC adjustmenta | 0 | −19.32 (−28.03 to −9.56) | −16.22 (−27.17 to −3.61) | −7.29 (−23.05–11.71) | 0 | −7.90 (−16.47–1.55) | −8.09 (−18.83–4.06) | 5.22 (−9.12–21.84) |
| Lean Mass Index (kg/m2)—Quartiles | Lean Mass Index (kg/m2)—Quartiles | |||||||
| Q1 (13.5–18.3) | Q2 (18.3–19.9) | Q3 (19.9–21.5) | Q4 (21.5–38.0) | Q1 (11.4–14.9) | Q2 (14.9–16.3) | Q3 (16.3–18.2) | Q4 (18.2–31.6) | |
| Mean (95% CI), pg/mL | 32.18 (29.28–35.36) | 27.66 (25.37–30.17) | 24.66 (22.71–26.79) | 22.29 (20.63–24.08) | 74.12 (69.34–79.23) | 63.40 (59.49–67.56) | 58.08 (53.47–63.08) | 45.49 (42.09–49.17) |
| % difference (95% CI) | 0 | −9.78 (−17.69 to −1.11) | −19.73 (−27.80 to −0.77) | −20.53 (−28.10 to −12.16) | 0 | −9.07 (−15.91 to −1.68) | −17.36 (−25.32 to −8.55) | −32.43 (−36.94 to −27.60) |
| % difference (95% CI)—FMI adjustmenta | 0 | −8.88 (−16.76 to −0.26) | −18.32 (−27.11 to −8.46) | −18.02 (−27.89 to −6.81) | 0 | −9.13 (−16.18 to −1.47) | −17.49 (−25.97 to −8.04) | −32.64 (−39.97 to −24.43) |
| % difference (95% CI)—BMI adjustmenta | 0 | −7.92 (−16.30–1.31) | −16.76 (−27.79–4.05) | −15.49 (−29.79–1.71) | 0 | −8.24 (−16.09–0.33) | −17.19 (−26.39 to −6.85) | −16.26 (−26.48 to −4.62) |
| % difference (95% CI)—WC adjustmenta | 0 | −8.77 (−16.18 to −0.71) | −16.71 (−25.92 to −6.35) | −31.40 (−41.13 to −20.07) | −6.51 (−13.69 to 1.27) | −11.32 (−20.86 to −0.63) | −23.19 (−32.43 to −12.67) | |
Differences were adjusted for age, race, education, drinking, smoking, physical activity, diabetes, high cholesterol, hypertension, and estimated glomerular filtration rate (Iinear spline at 60).
a
indicates additional adjustment for the mentioned variable.