Table 4.
Association of measures of body composition and elevated NT-pro-BNP(≥ 125 pg/mL) among US adults aged 20 or older, NHANES 1999–2004.
| Men | Women | |||||||
|---|---|---|---|---|---|---|---|---|
| Waist Circumference (cm)—Quartiles | Waist Circumference (cm)—Quartiles | |||||||
| Q1 (62.4–89.3) | Q2 (89.4–97.9)) | Q3 (98.0–107.9) | Q4 (108.0–173.4) | Q1 (62.0–81.3) | Q2 (81.4–90.8) | Q3 (90.9–102.4) | Q4 (102.5–155.9) | |
| % with elevated NT-pro-BNP (95% CI) | 9.06 (0.99) | 11.76 (0.95) | 16.33 (1.08) | 16.81 (1.10) | 33.77 (1.88) | 37.77 (2.00) | 39.11 (1.40) | 33.99 (1.61) |
| Odds ratio (95% CI) | 1.00 (Reference) | 0.68 (0.49–0.94) | 0.70 (0.47–1.04) | 0.61 (0.43–0.87) | 1.00 (Reference) | 0.91 (0.70–1.20) | 0.75 (0.59–0.96) | 0.55 (0.42–0.74) |
| Body Mass Index—Clinical Categories | Body Mass Index—Clinical Categories | |||||||
| 18.5–<25 kg/m2 | 25–<30 kg/m2 | 30–<35 kg/m2 | BMI ≥ 35 kg/m2 | 18.5–<25 kg/m2 | 25–<30 kg/m2 | 30–<35 kg/m2 | BMI ≥ 35 kg/m2 | |
| % with elevated NT-pro-BNP (95% CI) | 13.61 (1.18) | 13.37 (0.72) | 14.07 (1.42) | 12.62 (1.88) | 37.61 (1.47) | 37.15 (1.49) | 34.35 (1.77) | 32.82 (2.23) |
| Odds ratio (95% CI) | 1.00 (Reference) | 0.68 (0.50–0.91) | 0.71 (0.49–1.04) | 0.67 (0.44–1.02) | 1.00 (Reference) | 0.79 (0.65–0.97) | 0.70 (0.55–0.89) | 0.67 (0.51–0.89) |
| Body Mass Index—Quartiles | Body Mass Index—Quartiles | |||||||
| Q1 (18.5–24.4) | Q2 (24.4–27.3) | Q3 (27.3–30.5) | Q4 (30.5–64.2) | Q1 (18.5–23.2) | Q2 (23.2–26.8) | Q3 (26.9–32.0) | Q4 (32.0–66.4) | |
| % with elevated NT-pro-BNP (95% CI) | 14.06 (1.27) | 13.38 (0.99) | 12.93 (1.01) | 13.68 (1.11) | 36.38 (1.97) | 39.11 (1.62) | 36.57 (1.79) | 32.59 (1.69) |
| Odd ratio (95% CI) | 1.00 (Reference) | 0.68 (0.49–0.94) | 0.61 (0.42–0.87) | 0.64 (0.47–0.89) | 1.00 (Reference) | 0.91 (0.73–1.15) | 0.76 (0.60–0.96) | 0.65 (0.51–0.83) |
| Fat Mass Index (kg/m2)—Quartiles | Fat Mass Index (kg/m2)—Quartiles | |||||||
| Q1 (2.2–6.0) | Q2 (6.0–7.7) | Q3 (7.7–9.6) | Q4 (9.6–27.7) | Q1 (3.7–8.4) | Q2 (8.4–11.0) | Q3 (11.0–14.2) | Q4 (14.2–36.4) | |
| % with elevated NT-pro-BNP (95% CI) | 11.13 (1.14) | 12.12 (1.04) | 13.79 (1.09) | 17.01 (1.25) | 35.22 (2.05) | 37.76 (1.70) | 36.42 (1.63) | 35.24 (1.69) |
| Odds ratio (95% CI) | 1.00 (Reference) | 0.54 (0.36–0.81) | 0.51 (0.33–0.80) | 0.61 (0.43–0.87) | 1.00 (Reference) | 0.78 (0.61–1.01) | 0.68 (0.56–0.82) | 0.65 (0.50–0.85) |
| Odds ratio (95% CI)—LMI adjustmenta | 1.00 (Reference) | 0.58 (0.37–0.89) | 0.58 (0.35–0.95) | 0.77 (0.46–1.28) | 1.00 (Reference) | 0.82 (0.63–1.06) | 0.76 (0.61–0.95) | 0.84 (0.56–1.27) |
| Odds ratio (95% CI)—BMI adjustmenta | 1.00 (Reference) | 0.57 (0.37–0.88) | 0.56 (0.33–0.96) | 0.73 (0.39–1.38) | 1.00 (Reference) | 0.80 (0.61–1.05) | 0.71 (0.52–0.96) | 0.72 (0.40–1.29) |
| Odds ratio (95% CI)—WC adjustmenta | 1.00 (Reference) | 0.52 (0.34–0.82) | 0.49 (0.29–0.83) | 0.56 (0.29–1.09) | 1.00 (Reference) | 0.87 (0.67–1.15) | 0.86 (0.64–1.15) | 1.01 (0.62–1.67) |
| Lean Mass Index (kg/m2)—Quartiles | Lean Mass Index (kg/m2)—Quartiles | |||||||
| Q1 (13.5–18.3) | Q2 (18.3–19.9) | Q3 (19.9–21.5) | Q4 (21.5–38.0) | Q1 (11.4–14.9) | Q2 (14.9–16.3) | Q3 (16.3–18.2) | Q4 (18.2–31.6) | |
| % with elevated NT-pro-BNP (95% CI) | 19.11 (1.43) | 13.27 (1.03) | 12.00 (1.05) | 9.67 (1.04) | 42.72 (1.94) | 38.43 (1.70) | 34.47 (1.64) | 29.10 (1.63) |
| Odds ratio (95% CI) | 1.00 (Reference | 0.69 (0.50–0.95) | 0.66 (0.47–0.94) | 0.58 (0.39–0.86) | 1.00 (Reference) | 0.93 (0.72–1.19) | 0.75 (0.58–0.98) | 0.59 (0.47–0.73) |
| Odds ratio (95% CI)—FMI adjustmenta | 1.00 (Reference) | 0.67 (0.49–0.92) | 0.63 (0.43–0.92) | 0.51 (0.29–0.91) | 1.00 (Reference) | 0.91 (0.71–1.16) | 0.70 (0.53–0.93) | 0.51 (0.37–0.70) |
| Odds ratio (95% CI)—BMI adjustmenta | 1.00 (Reference) | 0.65 (0.47–0.90) | 0.60 (0.39–0.92) | 0.48 (0.24–0.94) | 1.00 (Reference) | 0.89 (0.69–1.15) | 0.68 (0.50–0.92) | 0.47 (0.32–0.69) |
| Odds ratio (95% CI)—WC adjustmenta | 1.00 (Reference) | 0.66 (0.48–0.90) | 0.61 (0.41–0.91) | 0.49 (0.28–0.87) | 1.00 (Reference)0 | 0.96 (0.75–1.22) | 0.81 (0.61–1.08) | 0.69 (0.53–0.91) |
Odds ratios were adjusted for age, race, education, drinking, smoking, physical activity, diabetes, high cholesterol, hypertension, estimated glomerular fraction (linear spline at 60).
Elevated NT-pro-BNP corresponds to NT-pro-BNP ≥ 125 pg/mL.
a
indicates additional adjustment for the mentioned variable.