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. 2023 Sep 4;24:523. doi: 10.1186/s12864-023-09583-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Clinical correlation analysis of UBRs in pan-cancer. (A) The quantitative distribution of UBRs affecting patient survival. (B) Impact of hub genes on patient survival. (C) HRs distribution for specific genes. (D) Violin plot showing average expression of hub genes in different clusters. (E) The expression heatmap of hub gene in LUAD. (F) Kaplan-Meier survival plots for LUAD in different clusters. (G) PPI network between hub genes and clinically actionable genes. (H) Drug sensitivity analysis of hub genes. Color represents the correlation between gene expression and drug IC50. The size of the point is inversely related to the size of the p-value. The shape represents the state of the drug, the circle represents the drug in the clinical trial stage, and the triangle represents the drug that has been approved by the FDA