Fig. 1.

Cell fate of normal cells and metastatic tumor cells after losing adhesion to the extracellular matrix. When normal cells lose their adhesion to the extracellular matrix, apoptosis occurs because the body prevents the wrong connection of cells. However, after losing adhesion to the extracellular matrix due to its metastasis characteristics, tumor cells develop resistance, survive without adhesion to the extracellular matrix, and can flow to other tissues and organs through blood and lymph for adhesion and metastasis