Table 1.
General characteristics and clinical outcomes of patients with different endometrial preparation protocols
| Variables | 1:GnRH-a-HRT | 2:HRT | 3:OI | 4:NC | P value | ||
|---|---|---|---|---|---|---|---|
| No. of cases | 451 | 696 | 42 | 859 | - | ||
| Maternal age at FET, years | 32.29 ± 3.49 | 32.11 ± 3.53 | 32.71 ± 3.49 | 32.29 ± 3.40 | 0.551 | ||
| Duration of infertility, years | 3.50 ± 2.34 | 4.02 ± 2.67 | 3.74 ± 2.36 | 4.12 ± 2.68 | 0.001a | ||
| Body mass index, kg/m2 | 20.75 ± 2.45 | 20.80 ± 2.48 | 21.25 ± 2.83 | 20.69 ± 2.42 | 0.607 | ||
| Infertility diagnosis | Primary infertility, n (%) |
61.2% (276/451) |
54.7% (381/696) |
40.5% (17/42) |
59.4% (510/859) |
0.001a | |
| Secondary infertility, n (%) | 36.1%(163/451) | 43.5%(303/696) | 54.8%(23/42) | 40%(344/859) | |||
| Infertility-free b | 2.7%(12/451) | 1.7%(12/696) | 4.8%(2/42) | 0.6%(5/859) | |||
| Infertility etiology, n (%) | Tubal factor | 51.2%(231/451) | 56.8%(395/696) | 61.9%(26/42) | 63.7%(547/859) | 0.000a | |
| Male factor | 49.7%(224/451) | 47.6%(331/696) | 57.1%(24/42) | 47.4%(407/859) | 0.556 | ||
| Other | 33.9%(153/451) | 35.5%(247/696) | 19%(8/42) | 24.9%(214/859) | 0.000a | ||
| endometriosis ASRM stage c | ASRMI-II | 14.6%(66/451) | 45.7%(318/696) | 50%(21/42) | 51.2%(440/859) | 0.000a | |
| ASRMIII-IV | 85.4%(385/451) | 54.3%(378/696) | 50%(21/42) | 48.8%(419/859) | |||
| endometriosis complicated with adenomyosis | 20.4%(92/451) | 3.6%(25/696) | 14.3%(6/42) | 3.3%(28/859) | 0.000a | ||
| Ovarian stimulation protocols, n (%) | Long GnRH-a | 55.2%(249/451) | 74.1%(516/696) | 69%(29/42) | 79.6%(684/859) | 0.000a | |
| GnRH-a ultra-long | 12.4%(56/451) | 4%(28/696) | 0%(0/42) | 2.1%(18/859) | |||
| GnRH antagonist | 24.8%(112/451) | 15.1%(105/696) | 26.2%(11/42) | 12.2%(105/859) | |||
| Other protocols | 7.5%(34/451) | 6.8%(47/696) | 4.8%(2/42) | 6.1%(52/859) | |||
| Gonadotropin dose, IU | 2621 ± 945 | 2325 ± 894 | 2748 ± 1038 | 2300 ± 848 | 0.000a | ||
| No. of oocytes retrieved | 12.15 ± 7.53 | 15.09 ± 8.9 | 14.5 ± 9.35 | 15.29 ± 8.43 | 0.000a | ||
| Blastocyst formation rate | 0.60 ± 0.28 | 0.56 ± 0.28 | 0.59 ± 0.28 | 0.56 ± 0.29 | 0.313 | ||
| Type of embryo transferred, n (%) | Cleavage embryo | 45.0%(203/451) | 42.1%(293/696) | 35.7%(15/42) | 45.5%(391/859) | 0.365 | |
| Blastocyst | 55.0%(248/451) | 57.9%(403/696) | 64.3%(27/42) | 54.5%(468/859) | |||
| No. of embryos transferred | 1.58 ± 0.57 | 1.71 ± 0.65 | 1.48 ± 0.51 | 1.78 ± 0.68 | 0.000a | ||
| No. of good quality embryos transferred | 1.15 ± 0.69 | 1.13 ± 0.78 | 0.93 ± 0.75 | 1.12 ± 0.78 | 0.287 | ||
| Rate of good quality embryos transferred | 83.8%(378/451) | 78.3%(545/696) | 69%(29/42) | 78.9%(678/859) | 0.033a | ||
| Clinical Pregnancy | 53.2%(240/451) | 49.7%(346/696) | 54.8%(23/42) | 46.8%(402/859) | 0.141 | ||
| Live Birth | 43.5%(196/451) | 39.8%(277/696) | 45.2%(19/42) | 39.0%(335/859) | 0.397 | ||
| Early Miscarriage | 15.4%(37/240) | 18.2%(63/346) | 17.4%(4/23) | 15.4%(62/402) | 0.732 | ||
Note: aP<0.05
bInfertility-free: Patients who did not meet the diagnostic criteria for infertility, mainly included patients treated with preimplantation genetic testing(PGT)
cendometriosis ASRM stage: The American Society of Reproductive Medicine distinguishes four stages of endometriosis, where stage I and II are fairly mild types, and stages III and IV are advanced disease