Table 3.
General characteristics and pregnancy outcomes of patients with different endometrial preparation protocols after PSM
| NC and GnRHa-HRT after PSM | HRT and GnRHa-HRT after PSM | |||||||
|---|---|---|---|---|---|---|---|---|
| NC | GnRHa-HRT | P value | HRT | GnRHa-HRT | P value | |||
| No. Of cases | 312 | 312 | - | 332 | 332 | - | ||
| Maternal age at FET, years | 32.27 ± 3.46 | 32.18 ± 3.56 | 0.959 | 32.12 ± 3.47 | 32.3 ± 3.52 | 0.479 | ||
| Duration of infertility, years | 3.68 ± 2.44 | 3.8 ± 2.5 | 0.562 | 3.61 ± 2.56 | 3.68 ± 2.47 | 0.542 | ||
| Body mass index, kg/m2 | 20.52 ± 2.36 | 20.6 ± 2.47 | 0.52 | 20.73 ± 2.27 | 20.66 ± 2.38 | 0.707 | ||
| Infertility diagnosis | Primary infertility, n (%) | 60.6%(189/312) | 63.5%(198/312) | 0.73 | 59.3%(197/332) | 59.3%(197/332) | 0.969 | |
| Secondary infertility, n (%) | 38.1%(119/312) | 35.6%(111/312) | 38%(126/332) | 38.3%(127/332) | ||||
| Infertility-free | 1.3%(4/312) | 1%(3/312) | 2.7%(9/332) | 2.4%(8/332) | ||||
| Infertility etiology, n (%) | Tubal factor | 58%(181/312) | 54.2%(169/312) | 0.333 | 55.4%(184/332) | 50.9%(169/332) | 0.243 | |
| Male factor | 47.8%(149/312) | 47.4%(148/312) | 0.936 | 52.4%(174/332) | 50.6%(168/332) | 0.641 | ||
| Other | 27.9%(87/312) | 30.8%(96/312) | 0.429 | 32.8%(109/332) | 34.3%(114/332) | 0.681 | ||
| endometriosis ASRM stage | ASRMI-II | 22.1%(69/312) | 21.2%(66/312) | 0.771 | 18.7%(62/332) | 19.6%(65/332) | 0.767 | |
| ASRMIII-IV | 77.9%(243/312) | 78.8%(246/312) | 81.3%(270/332) | 80.4%(267/332) | ||||
| endometriosis complicated with adenomyosis | 6.7%(21/312) | 6.1%(19/312) | 0.744 | 6.9%(23/332) | 6%(20/332) | 0.636 | ||
| Ovarian stimulation protocols, n (%) | Long GnRH-a | 66%(206/312) | 66.3%(207/312) | 0.986 | 64.5%(214/332) | 64.2%(213/332) | 0.951 | |
|
GnRH-a ultra-long |
5.1%(16/312) | 4.8%(15/312) | 6.9%(23/332) | 6.3%(21/332) | ||||
| GnRH antagonist | 21.2%(66/312) | 20.5%(64/312) | 19.9%(66/332) | 21.4%(71/332) | ||||
| Other protocols | 7.7%(24/312) | 8.3%(26/312) | 8.7%(29/332) | 8.1%(27/332) | ||||
| Gonadotropin dose, IU | 2338.82 ± 878.17 | 2532.28 ± 966.03 | 0.009a | 2471.42 ± 936.87 | 2533.49 ± 979.57 | 0.433 | ||
| No. of oocytes retrieved | 12.99 ± 7.84 | 13.37 ± 7.84 | 0.358 | 13.08 ± 8.15 | 12.6 ± 7.76 | 0.615 | ||
| Blastocyst formation rate | 0.61 ± 0.29 | 0.59 ± 0.26 | 0.389 | 0.60 ± 0.27 | 0.60 ± 0.28 | 0.936 | ||
| Type of embryo transferred, n (%) | Cleavage embryo | 44.9%(140/312) | 45.5%(142/312) | 0.872 | 47.9%(159/332) | 47.6%(158/332) | 0.938 | |
| Blastocyst | 55.1%(172/312) | 54.5%(170/312) | 52.1%(173/332) | 52.4%(174/332) | ||||
| No. of embryos transferred | 1.69 ± 0.66 | 1.59 ± 0.56 | 0.036a | 1.71 ± 0.62 | 1.60 ± 0.55 | 0.018a | ||
| No. of good quality embryos transferred | 1.11 ± 0.69 | 1.14 ± 0.71 | 0.573 | 1.18 ± 0.69 | 1.17 ± 0.71 | 0.814 | ||
| Rate of good quality embryos transferred | 81.7%(255/312) | 82.4%(257/312) | 0.835 | 84.3%(280/332) | 83.1%(276/332) | 0.674 | ||
| Clinical Pregnancy | 48.1%(150/312) | 53.5%(167/312) | 0.173 | 52.1%(173/332) | 50.9%(169/332) | 0.756 | ||
| Live Birth | 41.7%(130/312) | 43.6%(136/312) | 0.627 | 42.2%(140/332) | 43.1%(143/332) | 0.814 | ||
| Early Miscarriage | 12.7%(19/150) | 15%(25/167) | 0.554 | 17.9%(31/173) | 11.8%(20/169) | 0.114 | ||
Note: aP<0.05