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. Author manuscript; available in PMC: 2023 Sep 5.
Published in final edited form as: Nat Genet. 2022 Dec 1;54(12):1853–1864. doi: 10.1038/s41588-022-01230-9

Extended Data Fig. 3: Key features of mutational signature clusters and associated survival outcomes.

Extended Data Fig. 3:

a, Summary of the key clinical and genomic features of each mutational signature cluster. Clusters are ordered top to bottom by lowest to highest proportion of long-term survivors (LTS) in each cluster. HR, homologous recombination; LOH, loss-of-heterozygosity; SV, structural variant; MTS, moderate-term survivor; STS, short-term survivor; DUP, duplications; DEL, deletions; INV, inversions. b, Kaplan–Meier analysis of progression-free and c, overall survival in patients stratified by signature clusters. P values calculated by Mantel–Cox log-rank test and dotted lines indicate median survival. d, Boxplots summarize the proportion (y-axis) of clustered and nonclustered rearrangements by size (x-axis) and type, for each mutational signature cluster (SIG.1 n = 14, SIG.2 n = 25, SIG.3 n = 13, SIG.4 n = 27, SIG.5 n = 22, SIG.6 n = 9, SIG.7 n = 16); boxes show the interquartile range (25–75th percentiles), central lines indicate the median, whiskers show the smallest/largest values within 1.5 times the interquartile range and values outside it are shown as individual data points. Del, deletions; tds, tandem duplications; inv, inversions, tra, interchromosomal translocations; Kb, kilobase; Mb, megabase.