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. 2023 Sep 5;29:120. doi: 10.1186/s10020-023-00709-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Hypo-ADSCs-Exo sustained coupled subchondral bone remodeling of LFJOA and attenuated the aberrant H-type vessels formation in subchondral bone. (A) Osteocalcin (OCN) staining (left panel) and TRAP staining (middle panel) in the subchondral bone of LFJ among different groups. Arrows point out the positive staining. Representative immunofluorescence of CD31 (Green), and Endomucin (Red) for H type vessel in the subchondral bone of LFJ among four groups (right panel). All images were captured under 40x objective lens. Scale bar=50 μm; (B-C) The statistical analysis of the ratio of OCN (B) and TRAP (C) positive cells in the subchondral bone of LFJ. (D) The statistical results of the double staining positive (CD31⁺ Endomucin⁺) cells in the subchondral bone of LFJ. All data are shown as the mean ±standard deviation (SD). n=6 per group. **p ＜ 0.01, compared with PBS treated group mice, ^#p ＜ 0.05, ^##p ＜ 0.01, compared with ADSCs-Exo mice