Table 3.
Commonly dysregulated lncRNAs in the PPs and iPSC derived pancreatic islets from FOXA2−/− iPSCs in comparison to that derived from WT-iPSCs
| Pancreatic progenitors (PPs) | β-cell stage | |||
|---|---|---|---|---|
| LncRNA | Log2 FC | p-value | Log2 FC | p-value |
| Downregulated | ||||
| LINC02864 | -4.972279036 | 0.000123222 | -2.98476449 | 0.002945274 |
| MEG3 | -4.373714533 | 0.004838358 | -1.695537434 | 8.06821E-05 |
| AL133325.3 | -3.99598566 | 0.0026067 | -2.737498389 | 0.000396846 |
| H19 | -3.36547207 | 0.00485596 | -1.050888105 | 0.006823965 |
| ZNF667-AS1 | -3.243039847 | 6.19752E-05 | -2.717560856 | 0.000210262 |
| CU634019.6 | -3.194862483 | 0.039922842 | -1.192479958 | 0.008498683 |
| AC069277.1 | -3.114859224 | 9.29544E-05 | -2.679374923 | 0.000701003 |
| LINC00543 | -3.09914005 | 0.001683363 | -1.29696446 | 0.001586351 |
| LINC00261 | -3.075824167 | 0.016451323 | -1.650881593 | 9.75487E-05 |
| AL161908.1 | -2.757967046 | 0.002944123 | -1.200190615 | 0.026481698 |
| AC097639.1 | -2.647646886 | 0.002050943 | -1.541881067 | 0.01047655 |
| AL035661.1 | -2.278195817 | 0.004812208 | -2.108152808 | 0.002375826 |
| AC092171.3 | -2.272636845 | 0.000741109 | -1.147031159 | 0.000704907 |
| MIR31HG | -2.222944778 | 0.02063138 | -1.301936215 | 0.027976252 |
| FAM215B | -2.169039549 | 0.015553135 | -1.089686542 | 0.017146332 |
| AC011503.2 | -2.152742951 | 0.000603108 | -1.970352528 | 9.47392E-05 |
| AC073046.1 | -2.132161904 | 0.006396904 | -1.286680951 | 0.017689242 |
| SLC25A25-AS1 | -1.9302323 | 0.025532882 | -1.05349219 | 0.008940334 |
| AC048382.2 | -1.858513511 | 0.001210312 | -1.164296471 | 0.030130827 |
| AC244636.3 | -1.804998996 | 0.011401985 | -1.102553403 | 0.000384212 |
| AC016590.3 | -1.64726758 | 0.01512032 | -1.656663538 | 0.000219614 |
| AC018521.6 | -1.569659776 | 0.004432069 | -1.147751692 | 0.011001064 |
| AL591684.2 | -1.46522189 | 0.006228583 | -1.097860713 | 0.012037403 |
| U73166.1 | -1.429991468 | 0.029312295 | -1.570767863 | 0.007890927 |
| AL512625.1 | -1.352837672 | 0.018258575 | -1.04791555 | 0.002257768 |
| AC006116.11 | -1.27904533 | 0.005817342 | -1.230767621 | 0.040102747 |
| ZNF790-AS1 | -1.229759258 | 0.007887571 | -1.352811357 | 0.00145091 |
| AL021395.1 | -1.22320025 | 0.021478149 | -1.456225426 | 0.000491092 |
| MNX1-AS2 | -1.220972989 | 0.016022764 | -1.119116833 | 0.011214612 |
| AC091563.1 | -1.142586895 | 0.002025041 | -1.852901184 | 0.000864753 |
| AL121761.1 | -1.096367847 | 0.013523216 | -2.47631697 | 0.002825188 |
| AC007403.1 | -1.083637207 | 0.015727536 | -1.197241732 | 0.000293157 |
| AC244197.2 | -1.061029505 | 0.0288463 | -1.701001108 | 0.004129482 |
| AC122129.1 | -1.053981503 | 0.007871661 | -1.338206292 | 0.01405125 |
| LINC01806 | -1.023333368 | 0.023463599 | -1.207405254 | 0.013336001 |
| Upregulated | ||||
| AC108865.2 | 2.76635816 | 0.02203366 | 2.16623553 | 0.01491233 |
| PANCR | 1.68884068 | 0.00676697 | 1.32679449 | 0.04815831 |
| AP001528.1 | 1.63797665 | 0.00049588 | 1.31355731 | 0.00045822 |
| LINC02732 | 1.52230916 | 0.03275826 | 1.50124372 | 0.02094184 |
| LINC01357 | 1.40909594 | 0.01116811 | 1.08663066 | 0.00471372 |
| AC111000.4 | 1.36919958 | 0.04373589 | 1.70320464 | 0.00042295 |
| AP000547.3 | 1.28967432 | 0.00223951 | 1.14135645 | 0.00160776 |
| AC140479.5 | 1.14460205 | 0.030656 | 1.10003456 | 0.00085757 |