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. 2023 Sep 4;14:20417314231197604. doi: 10.1177/20417314231197604

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© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — Verification of the anti-photo-aging repair function of EVs in vivo: (a) experimental protocol for photoaging mice modeling and EV treatment, (b) images captured from mice skin after 3 weeks of treatment with different EVs, (c) the degree of skin epithelium thickening and the degree of collagen disorder, the scale bar represents 500 μm, (d) statistics of mice epithelial thickness (n = 5), (e) expression of epithelial tissue aging and regeneration-related proteins, (f) and Quantitative analysis of gray values. Data are expressed as mean plus and minus standard deviations, *p < 0.05, **p < 0.01, ***p < 0.001.