Table 5.

Associations between phenotypes and age at natural menopause, MRS^a total score, and MRS domain scores, all adjusted for hormone therapy use

	Age at menopausec		MRS total		MRS psychological		MRS somatic		MRS urogenital
	Difference (95% CI)	p	Difference (95% CI)	p	Difference (95% CI)	p	Difference (95% CI)	p	Difference (95% CI)	p
CYP1A2b	1.08 (−5.71, 7.88)	0.75	−2.29 (−7.98, 3.40)	0.42	−1.22 (−4.13, 1.69)	0.41	−1.10 (−3.34, 1.13)	0.33	0.03 (−2.57, 2.64)	0.98
CYP3A4b	1.75 (−3.42, 6.92)	0.50	0.76 (−4.69, 6.21)	0.78	1.07 (−1.70, 3.85)	0.44	−1.81 (−3.90, 0.29)	0.09	1.49 (−0.96, 3.94)	0.23
CYP3A5b	−1.22 (−7.03, 4.59)	0.67	1.66 (−3.69, 7.01)	0.54	1.35 (−1.38, 4.07)	0.33	−1.16 (−3.25, 0.94)	0.27	1.48 (−0.94, 3.89)	0.23
CYP3A7b	1.88 (−3.01, 6.77)	0.44	−0.02 (−6.36, 6.33)	0.99	1.21 (−2.02, 4.45)	0.46	−0.17 (−2.67, 2.33)	0.89	−1.06 (−3.93, 1.82)	0.46
UGT1A1b	−2.24 (−5.68, 1.21)	0.20	−1.25 (−5.48, 2.99)	0.56	−0.94 (−3.10, 1.22)	0.39	0.97 (−0.68, 2.63)	0.24	−1.28 (−3.18, 0.63)	0.18
SLCO1B1b	1.63 (−3.99, 7.25)	0.56	1.77 (−5.48, 9.02)	0.63	0.99 (−2.72, 4.71)	0.59	−1.10 (−3.95, 1.75)	0.44	1.87 (−1.40, 5.14)	0.26
COMTb	0.06 (−3.49, 3.60)	0.97	2.10 (−1.90, 6.09)	0.30	−0.51 (−2.57, 1.56)	0.63	1.22 (−0.33, 2.78)	0.12	1.38 (−0.42, 3.18)	0.13
SULT1A1b	−2.36 (−6.77, 2.05)	0.29	−1.85 (−7.56, 3.85)	0.52	−0.78 (−3.71, 2.14)	0.59	−0.23 (−2.49, 2.03)	0.84	−0.84 (−3.44, 1.76)	0.52

^aMenopause Rating Scale

^bEstimates are for lower activity vs higher activity phenotype group (as defined in Table 1)

^cOnly among 49 post-menopausal women with natural menopause