Table 3.
Cox proportional hazard regression analysis of OS in LABC.
| Terms | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (>50) | 0.571 (0.212, 1.534) | 0.266 | ||
| Menopausal status (Post) | 0.503 (0.182, 1.385) | 0.183 | ||
| Nodal status (N2-N3) | – | |||
| TNM stage (TNM3b-TNM3c) | 1.811 (0.515, 6.365) | 0.355 | ||
| Histological grade (poorly differentiated) |
– | |||
| ER (Positive) | 0.249 (0.086, 0.717) | 0.010 | ||
| PR (Positive) | 0.427 (0.154, 1.180) | 0.101 | ||
| Her-2 (Positive) | 1.222 (0.454, 3.292) | 0.691 | ||
| Ki67 (Elevated) | 2.814 (1.055, 7.505) | 0.039 | ||
| Molecular subtypes | 0.085 | |||
| Luminal B1 | 0.604 (0.063, 5.811) | 0.662 | ||
| Luminal B2 | 1.101 (0.100, 12.170) | 0.937 | ||
| TNBC | 4.299 (0.501, 36.921) | 0.184 | ||
| HER2-enriched | 1.928 (0.225, 16.531) | 0.549 | ||
| Hsp27 (Positive) | 6.213 (1.765, 21.869) | 0.004 | ||
| TopoIIα (Positive) | 0.147 (0.051, 0.425) | <0.001 | 0.214 (0.074, 0.619) | 0.004 |
For patients characterized by N1 nodal status or well-/moderately-differentiated tumors were all censored, HR (95%CI) could not be calculated by Cox regression. Statistically significant values (P < 0.05) are given in italics.