TABLE 3.
Comparison of performance of COVID-19 N antigen detection kits in different variants.
| Study name (Manu-facturer) |
Test name |
Detec -ted anti -gen |
Overall sensitivity | Sensitivity (Ct ≤ 25) | Sensitivity (Ct ≥ 25) | Specifi- city |
Refe- rences |
|||||||||
|
Non-
Delta/ non- Omicron |
Delta |
Omic- ron BA.1 |
Omic- ron BA.2 |
Non-
Delta/ non- Omicron |
Delta |
Omic- ron BA.1 |
Omic- ron BA.2 |
Non-
Delta/ non- Omicron |
Delta |
Omic- ron BA.1 |
Omic- ron BA.2 |
|||||
| Clinitest (Siemens Healthineers) | The Clinitest® Rapid COVIDNA19 Antigen test | N, S1, S1 NARBD, S2 |
NA | 72.9% | 69.6% | NA | NA | 95.6% | 94.1% | NA | NA | 32% | 0% | NA | NA | Bayart et al., 2022 |
| NewNAGene (NewNAgene Bio engineering) |
The NewNAgene COVIDNA19 Antigen Detection Kit | N | NA | 75.7% | 73.9% | NA | NA | 95.6% | 97.1% | NA | NA | 40% | 7.7% | NA | NA | |
| Boson (Xiamen Boson Biotech Co.) | The Boson Rapid SARSNA CoVNA2 Antigen Test Card |
N | NA | 77.1% | 78.3% | NA | NA | 97.8% | 97.1% | NA | NA | 40% | 23.1% | NA | NA | |
| Flowflex (Acon Laboratories) | The Flowflex COVIDNA19 Antigen Home Test | N | NA | 70% | 67.4% | NA | NA | 97.8% | 91.2% | NA | NA | 20% | 0% | NA | NA | |
| Sejoy (Hangzhou Sejoy Electronics and Instrument Co.) | The Sejoy SARSNA CoVNA2 Antigen Rapid Test Cassette |
N | NA | 74.3% | 73.9% | NA | NA | 95.6% | 97.1% | NA | NA | 36% | 7.7% | NA | NA | |
| Roche (Roche Diagnostics) | The Roche SARSNA CoVNA2 Rapid Antigen Test Nasal |
N | NA | 92.9% | 78.3% | NA | NA | 100% | 100% | NA | NA | 80% | 23.1% | NA | NA | |
| Clongene (Hangzhou Clongene Biotech Co) | LungeneNA COVIDNA19 Antigen Rapid Test Cassette |
N | 50% | NA | 67.1% | 56.5% | 94.4% | NA | 91.1% | 76.1% | 34.8% | NA | 21.7% | 18.2% | 98.08% | Osterman et al., 2023 |
| nal von minden (nal von minden GmbH) | Nadal COVIDNA19 Ag Test | N | 36% | NA | 58.6% | 58.6% | 83.3% | NA | 86.7% | 76.6% | 13% | NA | 8.7% | 22.7% | 98.08% | |
| Glallergen (Glallergen Co) | Novel Corona Virus (2019NAnCoV) Antigen Test Kit | N | 92% | NA | 48.6% | 50% | 100% | NA | 71.1% | 68.1% | 100% | NA | 8.7% | 13.6% | 96.15% | |
| Saier (Suzhou Soochow University Saier Immuno Biotech Co.) | InstantSure COVIDNA19 Ag CARD | N | 96% | NA | 55.7% | 55.7% | 100% | NA | 80% | 74.5% | 100% | NA | 13% | 18.2% | 98.08 | |
| Egens (Nantong Egens Bio-technology Co) | EGENS SarsNA CoVNA2 Antigen Rapid Test |
SARSNA CoVNA2 antigen |
90% | NA | 37.7% | 35.7% | 100% | NA | 52.3% | 44.7% | 100% | NA | 13% | 18.2 | 98.08% | |
| FUJIFILM (Fujifilm Cooperation) | FUJIFILM COVIDNA19 Ag Test | N | 38% | 34.9% | 22.2% | NA | 85% | 50% | 31.4% | NA | 10% | 5.6% | 0% | NA | 100% | Osterman et al., 2022 |
| Hotgen (Beijing Hotgen Biotech Co., Ltd.) | Novel Coronavirus 2019NAnCoV Antigen Test (Colloidal gold) | N | 56% | 56.2% | 35.6% | NA | 100% | 74.4% | 50% | NA | 47.8% | 22.2% | 0% | NA | 100% | |
| NanoRepro (NanoRepro AG) | NanoRepro SARSNA CoVNA2 Antigen Schnelltest (Viromed) |
N | NA | 53.9% | 31.7% | NA | 94.1% | 72.7% | 44.4% | NA | NA | 16.7% | 0% | NA | 100% | |
| CLINITEST (Healgen Scientific LLC) | CLINITEST Rapid COVIDNA19 Antigen Test | N | 76% | 55.4% | 35.6% | NA | 100% | 72.7% | 50% | NA | 87% | 22.2% | 0% | NA | 100% | |
| Lyher (Hangzhou Laihe Biotech Co., Ltd.) | Lyher Novel Coronavirus (COVIDNA19) Antigen Test Kit (Colloidal Gold) | N | 42% | 58.5% | 47.5% | NA | 94.4% | 77.3% | 63.9% | NA | 17.4% | 22.2% | 8.3% | NA | 100% | |
| Biosynex (Biosynex Swiss SA) | COVIDNA19 Ag BSS selfNAtest | N | 74% | 55.4% | 43% | NA | 100% | 75% | 60.6% | NA | 78.3% | 16.7% | 0% | NA | 100% | |
| Boson (Xiamen Boson Biotech Co., Ltd.) | rapid SARSNA CoVNA2 Antigen Test Card |
N | 54% | 49.2% | 29.7% | NA | 100% | 72.1% | 41.7% | NA | 43.5% | 0% | 0% | NA | 100% | |
| MP (MP Biomedicals Germany GmbH) | rapid SARSNA CoVNA2 Antigen Test Card |
NA | 54% | 58.5% | 51.5% | NA | 100% | 75% | 70.8% | NA | 43.5% | 27.8% | 4.2% | NA | 100% | |
| Medicovid NAAG (Xiamen Boson Biotech Co., Ltd.) |
Medicovid NAAG SARSNA CoVNA2 Antigen Rapid Test CardNAnasal |
NA | NA | 5 5.4% | 57.4% | NA | NA | 75% | 77.8% | NA | NA | 16.7% | 8.3% | NA | 100% | |
| Abbott N (Abbott Laboratories) | Abbott SARSNA CoVNA2 IgG assay |
N | NA | NA | NA | NA | NA | NA | 91.3% | NA | NA | NA | NA | NA | NA | Migueres et al., 2023 |
| InBios (InBios International Inc) | SCoVNA2 Ag Detect Rapid SelfNATest | N | 81.2% | 90.7% | 83.6% | NA | NA | NA | NA | NA | NA | NA | NA | NA | 99.8% | Bekliz et al., 2022 |
| Panbio (Abbott) | Panbio COVIDNA19 Ag Rapid test device | NA | NA | 67.7% | 36.1% | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | Bekliz et al., 2022 |
| SD Biosensor (Roche) | Standard Q COVIDNA19 Ag | N | NA | 52.9% | 22.2% | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Sure Status (Premier Medical Corporation) | Sure Status | N | NA | 52.9% | 27.8% | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Wondfo (Wondfo) | 2019NAnCoV Antigen test | N | NA | 76.5% | 75% | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Tigsun (Beijng Tigsun Diagnostics Co. Ltd) | N | NA | 52.9% | 47.2% | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | ||
| CTK biotech (Onsite) | Onsite COVIDNA19 Ag Rapid Test | N | NA | 64.7% | 47.2% | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Flowflex (ACON biotech) | N | NA | 91.2% | 88.9% | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | ||
| Bionote (Bionote) | NowCheck CovidNA19 Ag test | N | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| BinaxNOW™ (Abbott) | COVIDNA19 Ag AtNAHome Card | N | NA | 41% | 33% | NA | NA | 41% | 33% | NA | NA | 12% | 0% | NA | NA | Kanjilal et al., 2022 |
| AAZ (AAZ) | COVID-NAVIRO antigen rapid test | N | 92.3% | 81.5% | 89.5% | NA | 95.8% | 93.6% | 100% | NA | 50% | 0% | 69.2% | NA | 100% | Gourgeon et al., 2022 |
| AMP (AMP Diagnostics) | AMP rapid test SARSNA CoVNA2 Ag |
N | 94.2% | 92.6% | 92.1% | NA | 95.8% | 100% | 100% | NA | 75% | 42.9% | 76.9% | NA | 100% | |
| Novel (Medakit) | Novel coronavirus (COVIDNA19) antigen test kit | N | 90.0% | 87.0% | 89.5% | NA | 95.7% | 97.9% | 100% | NA | 25% | 14.3% | 69.2% | NA | 100% | |
| Biospeedia (Biospeedia) | BSDNA0500 333NA25NA COVID19 speed antigen test |
N | 92.0% | 88.9% | 89.5% | NA | 95.7% | 100% | 100% | NA | 50% | 14.3% | 69.2% | NA | 100% | |
| Siemens (Siemens Healthcare) | Test antigénique rapide Clinitest COVIDNA19 | N | 92.3% | 85.2% | 86.8% | NA | 95.8%% | 95.7% | 100% | NA | 50% | 14.3% | 61.5% | NA | 100% | |
Ct, Cycle threshold; Non-Delta/non-Omicron, The variants tested were neither Delta nor Omicron variants; NA, not available.