TABLE 1.
Estimated Absorbed Doses to Cultured Cells Using MIRDcell Version 3.11
| Subcellular distribution | Absorbed dose (Gy per 1.1 kBq/mL) | |||
|---|---|---|---|---|
| Activity in cytoplasm | Activity on cell surface | 225Ac | 225Ac plus daughters | 0.58 × D (225Ac plus daughters in cyto) plus 0.42 × D (225Ac on cell surface) |
| 0% | 100% | 0.42 | 1.58 | |
| 58% | 42% | 0.70 | 2.57 | 2.08 |
| 100% | 0% | 0.90 | 3.28 | |
D = absorbed dose.
Doses are assuming 0–100% internalization for 111In-Pr in assay and then extrapolated to 225Ac without daughters (column 3) and with daughters (column 4). Column 5 gives absorbed dose when daughters are included for 225Ac decays in cytoplasm (58%) and daughters are excluded for decays on cell surface (42%).