Figure 2.

RDH12-retinopathy fundus features. A) Ultrawide colour and autofluorescence fundus imaging of a 12-year-old boy with early onset severe retinal dystrophy (EOSRD). The macular atrophy presents the characteristic variegated watercolour-like pattern extending to the periphery. Peripheral retinal pigment epithelium (RPE) atrophy with minimal pigmented deposits, and peripapillary sparing, are also present. B) Macular Optical Coherence Tomography (OCT) from 8-, 18-, and 39-year-old individuals with EOSRD. We see loss of the outer layers with preserved overall retinal structure in the youngest patient, and a progressive loss of retinal architecture along with coloboma-like lesion formation in the older patients. C) Ultrawide fundus imaging from a 35-year-old individual with autosomal dominant retinitis pigmentosa. The mid-periphery appears mostly involved with pigmented bone spicules and RPE loss, while the macula and far periphery remains preserved. D) Ultrawide fundus imaging from a 13-year-old patient with macular dystrophy. We see a perifoveal area of atrophy with a hyperautofluorescent rim, preserved central and peripheral structure.