Skip to main content
. Author manuscript; available in PMC: 2023 Sep 5.
Published in final edited form as: Cell Rep. 2023 Jun 22;42(7):112671. doi: 10.1016/j.celrep.2023.112671

Figure 7. Selection of 5′-flanking bases by non-class III members of the ETS family.

Figure 7.

(A) Sequence alignment of the human ETS domains, sorted by the four classes.

(B) Binding motifs of the first listed member in each class as curated in the CIS-BP database.57

(C) One model in the NMR ensemble of the Ets1/DNA complex in which E387 H-bonds with the exocyclic NH2 of two 5′-flanking cytosines. Several other models show only one or the other cytosine being contacted.

(D) DNA-bound PDEF, whose aspartate (D303) does not reach 5′-flanking bases in the 5′-GGAA-3′ strand.

(E) Dipole moments (in debyes) of the four deoxynucleosides, which have been geometry optimized by density functional theory methods at the ωB97X-D/6-311+G(3df,2p) level. The tails of the arrow denote the partial-positive end.