Table 1.
Demographics, Severity, and Diagnoses at Study Entry
| Calfactant Group (n = 26) | Placebo Group (n = 17) | |
|---|---|---|
| Mean age, yr (SD) | 12.1 (6.1) | 12.8 (5.4) |
| Mean weight, kg (SD) | 45.1 (23.3) | 50.1 (28.7) |
| Mean height, cm (SD) | 142.2 (33.6) | 146.2 (29.3) |
| Mean BSA, m2 (SD) | 1.3 (.5) | 1.4 (.5) |
| Sex | ||
| Male | 16 (61.5) | 12 (70.6) |
| Female | 10 (38.5) | 5 (29.4) |
| Race (if known) | ||
| American Indian/Alaska | 1 (4.4) | 0 (0) |
| Native | ||
| Black or African American | 5 (21.7) | 2 (12.5) |
| White | 16 (69.6) | 14 (87.5) |
| More than 1 race | 1 (4.4) | 0 (0) |
| Ethnicity (if known) | ||
| Hispanic or Latino | 7 (31.8) | 8 (50.0) |
| Not Hispanic or Latino | 15 (68.2) | 8 (50.0) |
| Severity of illness* | ||
| Mean PRISM score (SD) | 19.8 (7.5) | 16.1 (4.7) |
| Risk strata | ||
| Leukemia | ||
| Lymphoma | 7 (26.9) | 11 (64.7) |
| Autologous HCT | ||
| Allogeneic HCT | 19 (73.1) | 6 (35.3) |
| Mean OI (SD) | 21.9 (12.2) | 22.6 (12.1) |
| Mean PaO2 (SD) | 77.7 (35.0) | 75.1 (26.1) |
| Mean Ph (SD) | 7.34 (.09) | 7.31 (.11) |
| Mean PaCO2 (SD) | 51.4 (18.7) | 52.8 (11.8) |
| Mean oxygen saturation (SD) | 93.4 (5.3) | 94.4 (4.9) |
| POPC | ||
| Good | 7 (29.2) | 3 (18.8) |
| Mild disability | 6 (25.0) | 3 (18.8) |
| Moderate disability | 7 (29.2) | 7 (43.8) |
| Severe disability | 3 (12.5) | 3 (18.8) |
| Coma/vegetative state | 1 (4.2) | 0 (0) |
| PCPC | ||
| Normal | 15 (62.5) | 7 (43.8) |
| Mild disability | 5 (20.8) | 4 (25.0) |
| Moderate disability | 2 (8.3) | 2 (12.5) |
| Severe disability | 1 (4.2) | 3 (18.8) |
| Coma/vegetative state | 1 (4.2) | 0 (0) |
| Causes of PARDS | ||
| Pneumonia | 17 (65.4) | 12 (70.6) |
| Viral | 8 (30.8) | 2 (11.8) |
| Protozoa | 0 (0) | 0 (0) |
| Idiopathic syndrome | 0 (0) | 5 (29.4) |
| Fungal | 2 (7.7) | 2 (11.8) |
| Radiation | 1 (3.9) | 0 (0) |
| Bacterial | 6 (23.1) | 2 (11.8) |
| Aspiration | 0 (0) | 1 (5.9) |
| Pulmonary hemorrhage | 1 (3.9) | 4 (23.5) |
| Pulmonary graft-versus-host disease | 1 (3.9) | 1 (5.9) |
| BOOP | 0 (0) | 1 (5.9) |
| Other† | 12 (46.2) | 6 (35.3) |
Values are n (%) unless otherwise defined. SD indicates standard deviation; BSA, body surface area; BOOP, bronchiolitis obliterans organizing pneumonia.
*
Measures represent the preintervention arterial blood gas if available; otherwise, the arterial blood gas on PICU admission was used.
†
Other category includes sepsis, bacteremia, human herpesvirus-6 without pneumonia, multiorgan dysfunction syndrome, secondary to Ara-C related inflammatory response, and others.