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. 2023 Sep 5;14:5408. doi: 10.1038/s41467-023-41119-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Four series of compounds synthesized via chemical hybridization. b In vitro inhibitor selectivity indices (SIs) and potencies against PvNMT (left graph), and in vitro inhibition concentrations of blood and liver stages of Plasmodium (right graph). Inhibitors displaying favorable inhibition profiles are labeled. Venn diagram highlights 12b and 30a as the most promising lead inhibitors.