Table 3.
IC50 values of NMT inhibitor compounds for cytotoxicity and effect on Plasmodium blood and liver stage infection
| Cytotoxicity | Blood stage | Liver stage | ||
|---|---|---|---|---|
| Compound | HepG2 IC50 (µM) | P. falciparum NF54 IC50 (nM) | P. vivax schizonts IC50 (µM) | P. vivax hypnozoites IC50 (µM) |
| 12a | >20 | 810 | 3–3.8 | 5.7 |
| 12b | >20 | 470 | 2.3–4.6 | 1.7 |
| 12d | >20 | 800 | 3.3–4.3 | 4.7 |
| 12e | >20 | 360 | 3.4–3.7 | 1.2 |
| 12f | >20 | 610 | 3.3–4.3 | 1.5 |
| 12g | >20 | 600 | 2.2–3.1 | 1.2 |
| 12j | >20 | 1250 | 4.9–6.0 | 12 |
| 12l | >20 | 370 | 2.9–4.7 | 2.1 |
| 12q | >20 | 380 | 2.2–3.5 | 4.4 |
| 26b | >20 | 710 | 3.1–4.1 | 4.6 |
| 26c | >20 | 820 | 2.8–4.2 | 4.2 |
| 26i | >20 | 400 | 3.3–5.2 | 11 |
| 30a | >20 | 440 | 2.9–4.3 | 2.1 |
| 30c | >20 | 680 | 2.7–4.9 | 3.8 |