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. 2023 Sep 5;80(9):276. doi: 10.1007/s00018-023-04924-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Blockade of IL-6 signalling reduces the effects of myofibroblast-conditioned medium and noncontact coculture on hiPSC-CM electrical function. A Spontaneous beating frequency of hiPSC-CM in control (black), conditioned medium (red), noncontact (blue) and contact coculture (purple), in the presence (diagonal pattern) or absence (no pattern) of a neutralising IL-6 antibody. Values expressed as means ± SEM (n = 16–20 treated monolayers). B, C Summary of APD50 (B) and APD90 (C) for hiPSC-CM in control, conditioned medium, noncontact and contact coculture, in the presence (diagonal pattern) or absence (no pattern) of a neutralising IL-6 antibody, at 1 Hz pacing rate. Values expressed as means ± SEM (n = 7–8 treated monolayers). D Average pacing rate needed to induce loss of 1:1 action potential capture in hiPSC-CM cultures. Values expressed as means ± SEM (n = 7–8 treated monolayers). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 (two‐way ANOVA with post hoc Tukey’s test)