Fig. 5.

Blockade of IL-6 signalling reduces the effects of myofibroblast-conditioned medium and noncontact coculture on hiPSC-CM calcium handling. A–E Time to Ca²⁺ transient peak (A), time to 50% Ca²⁺ decay (B), time to 80% Ca²⁺ decay (C), time from 50 to 80% Ca²⁺ decay (D) and rate of Ca²⁺ transient decay (E) for hiPSC-CM in control (black), conditioned medium (red), noncontact (blue) and contact coculture (purple), in the presence (diagonal pattern) or absence (no pattern) of a neutralising IL-6 antibody, at 1 Hz pacing rate. Values expressed as means ± SEM (n = 8–12 treated monolayers). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 (two‐way ANOVA with post hoc Tukey's test)