Fig. 8.

Effect of myofibroblast Cx43 silencing and IL-6 signalling blockade on hiPSC-CM electrical function and calcium handling following contact coculture. A–F APD50 (A), APD90 (B), time to Ca²⁺ transient peak (C), time to 50% Ca²⁺ decay (D), time to 80% Ca²⁺ decay (E) and rate of Ca²⁺ transient decay (F) for hiPSC-CM cultured in contact with control KD MyoFBs or Cx43-KD MyoFBs versus hiPSC-CM alone, in the presence (diagonal pattern) or absence (no pattern) of a neutralising IL-6 antibody, at 1 Hz pacing rate. Values expressed as means ± SEM (n = 3–9 treated monolayers). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 (two‐way ANOVA with post hoc Tukey’s test)