Table 3.
Survival analysis using the Kaplan–Meier method and Log-rank (Mantel-Cox) test
| Overall survival (days) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total population | GBM | CM | Pre-COVID group | COVID group | ||||||
| p-values | p-values | p-values | p-values | p-values | ||||||
| Cohort | ||||||||||
| Pre-COVID group | 199 | ns (0.1768) | 208 | ns (0.1075) | 198 | ns (0.8044) | ||||
| COVID group | 287 | 325 | 208 | |||||||
| Surgical procedure | ||||||||||
| Biopsy | 159 | 0.0002 | 154 | < 0.0001 | 168 | ns (0.4440) | 143 | 0.0002 | 185 | ns (0.1854) |
| Resection | 310 | 417 | 208 | 306 | 310 | |||||
| MGMT promoter status | ||||||||||
| Methylated | ─ | 310 | ns (0.2698) | ─ | ─ | ─ | ||||
| Not methylated | ─ | 296 | ─ | ─ | ─ | |||||
| Spread of metastasis | ||||||||||
| Only CNS involvement | ─ | ─ | 355 | 0.0064 | ─ | ─ | ||||
| Extra CNS involvement | ─ | ─ | 138 | ─ | ─ | |||||
| KPS | ||||||||||
| KPS ≥ 70 | 248 | ns (0.6596) | 296 | 0.4425 | 208 | ns (0.1222) | 208 | ns (0.6748) | 267 | ns (0.7314) |
| KPS < 70 | 234 | 520 | 93 | 92 | 387 | |||||
| RT | ||||||||||
| Yes | 342 | < 0.0001 | 376 | < 0.0001 | 295 | < 0.0001 | 339 | 0.292 | 310 | < 0.0001 |
| No | 49 | 39 | 69 | 198 | 80 | |||||