Skip to main content
. 2023 Aug 15;26(9):107646. doi: 10.1016/j.isci.2023.107646

Figure 7.

Figure 7

AT9283 and dorsomorphin inhibits HUVEC migration and tube formation

HUVECs were treated with Ang1 (200 ng/mL) in the presence or absence of AT9283 (or dorsomorphin) for 24 h.

(A–B) Representative images showing the healing of HUVECs treated with AT9283 and dorsomorphin at 0 h and 24 h after wounding. Bar, 200 μm.

(C–D) Quantification of the migration of HUVECs evaluated by wound healing assays. n = 6 in each group. ∗p < 0.05 vs. control, #p < 0.05 vs. Ang1.

(E–F) Transmigrated cells were measured using Boyden chamber assays. Bar, 50 μm.

(G–H) Representative images showing tube formation from HUVECs at 3 h after AT9283 and dorsomorphin treatment. Bar, 100 μm.

(I–J) Quantification of total length measured by tube-formation assays. n = 6 in each group. ∗p < 0.05 vs. control, #p < 0.05 vs. Ang1. Data are shown as mean ± SEM. DM, Dorsomorphin.