Table 4.
The experimental results of CLK1 kinase activity for five lead candidates. Each number in the table represents the protein activity ratio relative to control. The activity column shows the result of two experiments for each compound. Compounds in bold indicate the activity is less than 55%. The mean activity column displays the average value and standard deviation in each experiment.
| Compounds (@ 1 μM) | Activity | Mean Activity |
|---|---|---|
| (% Control) | (% Control) | |
| AGD22000100002 | 78 | 75(3.0) |
| 72 | ||
| AGD22000100003 | 101 | 99(2.5) |
| 96 | ||
| AGD22000100006 | 52 | 49(3.0) |
| 46 | ||
| AGD22000100008 | 52 | 51(1.0) |
| 50 | ||
| AGD22000100009 | 145 | 155(10.0) |
| 165 | ||