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. 2023 Sep 5;13:14632. doi: 10.1038/s41598-023-41092-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Co-expression of EfAb promotes increased levels and enhances the half-life of serum VNA-TcdB. (a) Table summarizing the dosing and sampling schedule for gnotobiotic piglets in (b) and (c). †Termination of individual animals. In group 2, following Day 5, only a single animal remained in the study. (b) Quantification of VNA-TcdB levels in piglets (V_HH detection ELISA) following a single intravenous injection of mRNA-LNP encoding VNA-TcdB, either together with mRNA-LNP encoding EfAb (depicted in Fig. 5c; n = 2) or a control mRNA-LNP (n = 2; n = 1 following day 5, control mRNA encoded a non-translated GFP) or VNA-TcdB alone (n = 1). Serum VNA-TcdB values were determined by V_HH detection ELISA (Supplement Table 2). Data is depicted as mean. Error bars represent the SD of two replicates. (c) PK profile of co-administered EfAb in piglets which had received. a single intravenous injection of mRNA-LNP encoding EfAb together with mRNA-LNP encoding VNA-TcdB (depicted as lime group in Fig. 5b) were determined using Total human IgG ELISA (Supplement Table 3). Data is depicted as mean. Error bars represent the SD of two replicates.