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. 2023 Sep 5;13:14622. doi: 10.1038/s41598-023-41632-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Results of cell tracking assay showing the mean, maximum (max) and minimum (min) speed of control cells either untreated or treated with EVs derived from control fibroblasts, EVs derived from a COL6-RD muscular dystrophy patient with an intermediate phenotype and a COL6-RD muscular dystrophy patient with a mild phenotype. Continuous lines represent comparisons with untreated control fibroblasts, dashed lines with control cells treated with EVs derived from control fibroblasts and dotted lines between control cells treated with EVs from either mild or intermediate COL6-RD fibroblasts. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 (b) Representative image of labelled EV´s incorporation in control fibroblasts in vivo.