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. 2023 Sep 5;14(9):590. doi: 10.1038/s41419-023-06092-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A, B RTCA confirmed that lenvatinib inhibited the proliferation of OZ and RBE cells. C, D Lenvatinib inhibited the migration and invasion of OZ and RBE cells. E, F The expression levels of E-cadherin and N-cadherin in OZ and RBE cells were detected by Western blotting. G Establishment of the model diagram of the ICC-PDX model. H CT images of tumors in ICC patients. I, J Hematoxylin-eosin staining analysis showed that the PDX model tumor were homologous to the patient’s tumor. K–M Tumor volume and tumor weight changed after lenvatinib treatment. N E-cadherin and N-cadherin protein expression in the PDX model was detected by Western blotting. *p < 0.05, ***p < 0.001, and ****p < 0.0001.