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. 2023 Sep 5;14(9):590. doi: 10.1038/s41419-023-06092-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A, B The protein expression levels of H3K27Ac and HDAC1 were detected in OZ and RBE cells after lenvatinib treatment by Western blotting. C, D The protein expression levels of H3K27Ac and HDAC1 in the PDX model after lenvatinib treatment. E AZGP1 and H3K27Ac expression was detected in OZ and RBE cells after lenvatinib treatment using immunofluorescence. F, G The expression level of H3K27Ac in the AZGP1 promoter region of OZ and RBE cells treated with lenvatinib was detected by ChIP. ns, nonsignificant. *p < 0.05, and **p < 0.01.