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. 2023 Aug 4;42(8):112875. doi: 10.1016/j.celrep.2023.112875

Figure 6.

Figure 6

The knockdown of mtrA potentiates frontline TB drugs

Colony-forming units (CFU) of Mtb over a period of 7 days for untreated (solid lines) and 0.018 μg/mL isoniazid or 0.006 μg/mL rifampicin-treated (dotted lines) liquid cultures of uninduced (black, minus ATc) and induced (orange, plus ATc) CRISPRi knockdown of mtrA with sgRNA5. Error bars show the standard deviation from three biological samples and gray dotted lines represent the limit of detection. Representative results from two experiments are presented. ATc, anhydrotetracycline inducer.