REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
dsRNA	SCICONS	10010500
TUBB3	BioLegend	802001; RRID: AB_2564645
Nucleocapsid	GeneTex	GTX135357; RRID: AB_2868464
Trk.B	Rnd Systems	AF1494; RRID: AB_2155264
Trk.C	Rnd Systems	MAB373; RRID: AB_2155422
Ret	abcam	ab134100; RRID: AB_2920824
Trk.A	Abcam	ab216626
CGRP	abcam	ab81887; RRID: AB_1658411
Bacterial and virus strains
SARS-CoV-2 strain USA-WA1/2020	BEI Resources	N/A
SARS-CoV-2 variants B.1.617.2/Delta	MassCPR variant repository	N/A
SARS-CoV-2 variants Omicron	MassCPR variant repository	N/A
Chemicals, peptides, and recombinant proteins
BDNF	Peprotech	450-02
GDNF	Peprotech	450-10
NT3	Peprotech	450-03
FGF2	Peprotech	100-18B
EGF	Peprotech	AF-100-15
CHIR99021	Biogems	2520691
Rock inhibitor	Fischer Scientific	688000100MG
DAPI	ThermoFischer	62248
Critical commercial assays
StemDiff Neural Crest Differentiation Kit	StemCell Technologies	08610
Split-seq library kit	Parse Biosciences	WT Mini V2
Deposited data
Raw and analyzed	This paper	GSE227530
Experimental models: Cell lines
Human iPSC 7095	This paper	AG07095
Calu-3 cell line	ATCC	HTB-55
HEK293T cells	ATCC	CRL-3216
Oligonucleotides
ACE2 gene expression Fwd: caagagcaaacggttgaacac	This paper	N/A
ACE2 gene expression Rev: ccagagcctctcattgtagtct	This paper	N/A
RPLP0 gene expression Fwd: gcagcatctacaaccctgaag	This paper	N/A
RPLP0 gene expression Rev: gcagacagacactggcaaca	This paper	N/A
Software and algorithms
STAR	Dobin et al.45	https://github.com/alexdobin/STAR
DESeq2	Love et al.47	https://bioconductor.org/packages/release/bioc/html/DESeq2.html
Cufflinks	Trapnell et al.48	http://cole-trapnell-lab.github.io/cufflinks
Seurat	Hao et al.49	https://satijalab.org/seurat/