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(A) ZNF382 ChIP-exo signals mapped onto LINE-1 ORF2 repeat coordinates; (B) PFM of L1-ZNF382 locus for each sub-group; (C) PEM derived from ZNF382 Spec-seq data; (D) Predicted energy distribution for all sites lifted out of each sub-group; (E) Arms race model between LINE-1 and ZNF382; (F) Mutagenesis effects at L1-ZNF382 locus (19).
