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. 2023 Aug 23;17:1217368. doi: 10.3389/fncel.2023.1217368

FIGURE 2.

FIGURE 2

Effect of seizurogenic compounds on fEPSP slope in stratum radiatum. (i) The time courses of the slope of the fEPSP after application of ACSF, vehicle (Veh), and each compound [(A) picrotoxin (PiTX), (B) gabazine (GZ), (C) 4-amino pyridine (4AP), and (D) pilocarpine (Pilo)] over a series of three ascending concentrations [Low, Mid (middle), High] for a period of 20 min per concentration. The stimulus -response S, R relationship was done in each concentration of the test compound (red solid line). (ii) Mean data summary of compound effects on EPSP slopes. The mean fEPSP slopes were determined for 10 data points of the fEPSP slopes (open arrowhead) before (S-R) relationship. All error bars, ± SEM from n = 8 to 16 slices. *p < 0.05; ***p < 0.001; ns, not significant (Dunnett’s test). fEPSPs, field excitatory postsynaptic potentials; EPSP, excitatory postsynaptic potentials; Mid., middle.