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. 2023 Sep 5;330(9):821–831. doi: 10.1001/jama.2023.14330

Table 2. Outcomes by Randomization Group.

Systolic blood pressure target, mm Hg Absolute difference (95% CI), mm Hg Regression coefficient (95% CI) P value for futility
<140 <160 ≤180 <140 vs ≤180 <160 vs ≤180
Primary outcomes, mean (95% CI)
Follow-up infarct volume at 36 h, mL 32.4 (18.0 to 46.7) [n = 38] 50.7 (33.7 to 67.7) [n = 36] 46.4 (24.5 to 68.2) [n = 39] −14.0 (−39.8 to 11.8) 4.3 (−22.9 to 31.6) −0.29 (−0.81 to ∞)a .99
Utility-weighted mRS score at 90 d 0.51 (0.38 to 0.63) [n = 37] 0.47 (0.35 to 0.60) [n = 39] 0.58 (0.46 to 0.71) [n = 37] −0.08 (−0.25 to 0.10) −0.11 (−0.29 to 0.07) −0.0019 (−∞ to 0.0017)b .93
Secondary outcomes, No./total (%) c
Any ICH ≤36 h 14/39 (36) 12/37 (32) 12/40 (30) 5.9 (−14.8 to 26.6) 2.4 (−18.3 to 23.1)
Symptomatic ICH ≤36 h 2/37 (5) 1/35 (3) 2/37 (5) 0 (−10.3 to 10.3) −2.5 (−11.7 to 6.6)
Post hoc outcomes c
In-hospital mortality, No./total (%) 3/40 (7.5) 6/40 (15) 3/40 (7.5) 0 (−11.5 to 11.5) 7.5 (−6.3 to 21.3)
24-hour NIHSS score, mean (95% CI) 11 (8 to 14) [n = 38] 12 (9 to 15) [n = 37] 7 (5 to 10) [n = 37] 3.9 (−0.2 to 7.9) 4.6 (0.6 to 8.6)

Abbreviations: ICH, intracerebral hemorrhage; mRS, modified Rankin Scale score; NIHSS, National Institutes of Health Stroke Scale.

a

Testing across all 3 groups, the regression coefficient denotes a 0.29 mL reduction in follow-up infarct volume with each mm Hg reduction in systolic blood pressure target after endovascular therapy (with a possibility of as much benefit as a 0.81-mL reduction and includes the regions of harm).

b

Testing across all 3 groups, the regression coefficient denotes a 0.0019 reduction in utility-weighted mRS score with each mm Hg reduction in systolic blood pressure target after endovascular therapy (with a small possible benefit of 0.0017 gain in utility and includes the regions of harm).

c

Secondary outcomes and in-hospital mortality absolute differences are presented as percentages.