Table 2. Outcomes by Randomization Group.
Systolic blood pressure target, mm Hg | Absolute difference (95% CI), mm Hg | Regression coefficient (95% CI) | P value for futility | ||||
---|---|---|---|---|---|---|---|
<140 | <160 | ≤180 | <140 vs ≤180 | <160 vs ≤180 | |||
Primary outcomes, mean (95% CI) | |||||||
Follow-up infarct volume at 36 h, mL | 32.4 (18.0 to 46.7) [n = 38] | 50.7 (33.7 to 67.7) [n = 36] | 46.4 (24.5 to 68.2) [n = 39] | −14.0 (−39.8 to 11.8) | 4.3 (−22.9 to 31.6) | −0.29 (−0.81 to ∞)a | .99 |
Utility-weighted mRS score at 90 d | 0.51 (0.38 to 0.63) [n = 37] | 0.47 (0.35 to 0.60) [n = 39] | 0.58 (0.46 to 0.71) [n = 37] | −0.08 (−0.25 to 0.10) | −0.11 (−0.29 to 0.07) | −0.0019 (−∞ to 0.0017)b | .93 |
Secondary outcomes, No./total (%) c | |||||||
Any ICH ≤36 h | 14/39 (36) | 12/37 (32) | 12/40 (30) | 5.9 (−14.8 to 26.6) | 2.4 (−18.3 to 23.1) | ||
Symptomatic ICH ≤36 h | 2/37 (5) | 1/35 (3) | 2/37 (5) | 0 (−10.3 to 10.3) | −2.5 (−11.7 to 6.6) | ||
Post hoc outcomes c | |||||||
In-hospital mortality, No./total (%) | 3/40 (7.5) | 6/40 (15) | 3/40 (7.5) | 0 (−11.5 to 11.5) | 7.5 (−6.3 to 21.3) | ||
24-hour NIHSS score, mean (95% CI) | 11 (8 to 14) [n = 38] | 12 (9 to 15) [n = 37] | 7 (5 to 10) [n = 37] | 3.9 (−0.2 to 7.9) | 4.6 (0.6 to 8.6) |
Abbreviations: ICH, intracerebral hemorrhage; mRS, modified Rankin Scale score; NIHSS, National Institutes of Health Stroke Scale.
Testing across all 3 groups, the regression coefficient denotes a 0.29 mL reduction in follow-up infarct volume with each mm Hg reduction in systolic blood pressure target after endovascular therapy (with a possibility of as much benefit as a 0.81-mL reduction and includes the regions of harm).
Testing across all 3 groups, the regression coefficient denotes a 0.0019 reduction in utility-weighted mRS score with each mm Hg reduction in systolic blood pressure target after endovascular therapy (with a small possible benefit of 0.0017 gain in utility and includes the regions of harm).
Secondary outcomes and in-hospital mortality absolute differences are presented as percentages.