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Ligand binding data for drug-metabolizing P450 enzymes ± fusion with the reductase FMN-containing domain
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The 95% confidence intervals are provided in gray.
a Substrates for CYP3A4, CYP2D6, and CYP2A6 were hydrocortisone, thioridazine, and coumarin, respectively. Kd units are μM except for hydrocortisone, which is mM.
b Inhibitors for CYP3A4, CYP2D6, and CYP2A6 were clotrimazole, prinomastat, and pilocarpine, respectively. Kd units are μM except for clotrimazole, which is nM.
