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. 2023 Aug 14;20(9):4546–4558. doi: 10.1021/acs.molpharmaceut.3c00240

Table 2. Composition of the Emulsion Formulationsa.

Formulation Dispersed Phase (% v/v) Stabilizer (% w/w) DLM (% w/w) DLM loading (%)
F1 15 1.5 1.0 40
F2 15 1.0 0.67 40
F3 15 0.5 0.33 40
F4 20 2.0 1.33 40
F5 25 2.5 1.67 40
F6 30 3.0 2.0 40
F7 40 4.0 2.67 40
a

The dispersed phase was dichloromethane and the continuous phase was aqueous. The stabilizer was either a cellulosic polymer or a 1:1 mass ratio of a cellulosic polymer to lecithin as a co-stabilizer. The dispersed phase content of each formulation is reported as a volume fraction, Inline graphic, where Vorganic is the volume of dichloromethane and Vtotal is the total volume of the organic and aqueous phases of the emulsion. Stabilizer and DLM concentrations are reported as a weight percent of the total mass of the liquid emulsion formulation. Drug loading is reported as a weight percent of the total mass of solid (nonvolatile) components of the emulsion, Inline graphic, where m denotes the mass of the respective components. For formulations containing two stabilizers (i.e., lecithin and a cellulosic stabilizer), the mass ratio of the stabilizers was 1:1.