Table 3. Z-Average Hydrodynamic Diameter and PDI over Time for F1 and F2 Emulsion Formulations Containing DLM and Stabilized by a 1:1 Ratio of HPMC to Lecithin Prepared by Probe-Tip Ultrasonication and High-Pressure Homogenization.
|
t ∼ 0 h |
t ∼ 3 h |
t ∼ 24 h |
|||||
|---|---|---|---|---|---|---|---|
| Formulation | Preparation method | Size (nm) | PDI | Size (nm) | PDI | Size (nm) | PDI |
| F1 | Ultrasonication | 251 ± 2 | 0.29 ± 0.01 | 276 ± 6 | 0.31 ± 0.01 | 292 ± 6 | 0.37 ± 0.02 |
| DLM/HPMC-lecithin | |||||||
| Homogenization | 222 ± 3 | 0.30 ± 0.03 | 233 ± 1 | 0.17 ± 0.03 | 293 ± 5 | 0.29 ± 0.02 | |
| F2 | Ultrasonication | 196 ± 3 | 0.12 ± 0.01 | 248 ± 4 | 0.05 ± 0.03 | 313 ± 3 | 0.16 ± 0.01 |
| DLM/HPMC-lecithin | |||||||
| Homogenization | 215 ± 1 | 0.22 ± 0.04 | 259 ± 5 | 0.32 ± 0.03 | 326 ± 7 | 0.28 ± 0.02 | |