Table 2.
Clinical manifestations at the time of meeting classification among 188 incident EULAR/ACR criteria-defined systemic lupus erythematosus cases, Olmsted County, Minnesota, 1976–2018. *
| EULAR/ACR Criteria | (N=188) |
|---|---|
|
| |
| n (%) | |
|
| |
| ANA positive | 188 (100) |
|
| |
| Clinical Criteria | |
|
| |
| Fever | 12 (6) |
| Leukopenia | 83 (44) |
| Thrombocytopenia | 32 (17) |
| Autoimmune hemolysis | 4 (2) |
| Delirium | 1 (1) |
| Psychosis | 0 (0) |
| Seizure | 2 (1) |
| Nonscarring alopecia | 5 (3) |
| Oral ulcers | 12 (6) |
| Subacute cutaneous OR discoid lupus | 21 (11) |
| Acute cutaneous lupus | 39 (21) |
| Pleural or pericardial effusion | 17 (9) |
| Acute pericarditis | 10 (5) |
| Arthritis | 102 (54) |
| Proteinuria | 15 (8) |
| Class II or V lupus nephritis | 3 (2) |
| Class III or IV lupus nephritis | 4 (2) |
|
| |
| Immunologic Criteria | |
|
| |
| Antiphospholipid antibodies | 24 (13) |
| Low C3 OR C4 | 41 (22) |
| Low C3 AND C4 | 27 (14) |
| Anti-dsDNA OR anti-Sm | 132 (70) |
Abbreviations: ANA=antinuclear antibodies; anti-dsDNA=anti-double-stranded DNA antibody; anti-Sm=anti-Smith antibody.
*
Systemic lupus erythematosus (SLE) cases were defined according to the European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria (met at least ten points, and at least one clinical criterion and ANA positivity). The clinical manifestation included were at the time the case met classification criteria.